|
Zhao [41]
|
2017
|
67.8 (7.5) / 68.5 (8.0)
|
50 / 50
|
China / diabetes
|
Parallel
|
0.1 g/d
|
42 weeks
|
Glucose and HbA1c
|
Not stated
|
Decrease
|
|
Cornelli-3mon [31]
|
2017
|
47.0 (3.75) / 46.4 (4.42)
|
48 / 49
|
Italy / obese
|
Parallel
|
1.6 g/d
|
13 weeks (3 month)
|
Glucose
|
Not stated
|
Decrease
|
|
Cornelli-6mon [31]
|
2017
|
47.0 (3.75) / 46.4 (4.42)
|
48 / 49
|
Italy / obese
|
Parallel
|
1.6 g/d
|
26 weeks (6 month)
|
Glucose
|
Not stated
|
Decrease
|
|
Cornelli-9mon [31]
|
2017
|
47.0 (3.75) / 46.4 (4.42)
|
48 / 49
|
Italy / obese
|
Parallel
|
1.6 g/d
|
38 weeks (9 month)
|
Glucose
|
Not stated
|
Decrease
|
|
Cornelli-12mon [31]
|
2017
|
47.0 (3.75) / 46.4 (4.42)
|
48 / 49
|
Italy / obese
|
Parallel
|
1.6 g/d
|
51 weeks (12 month)
|
Glucose
|
Not stated
|
No effect
|
|
Trivedi-90 day [42]
|
2016
|
36.3(10.5)/35.5(11.2)
|
64/32
|
India / overweight and obese
|
Parallel
|
2.5 g/d
|
12 weeks
|
HbA1c
|
Not stated
|
Decrease
|
|
Trivedi-45 day [42]
|
2016
|
36.3(10.5)/35.5(11.2)
|
64/32
|
India / overweight and obese
|
Parallel
|
2.5 g/d
|
6 weeks
|
HbA1c
|
Not stated
|
No effect
|
|
Kim [33]
|
2014
|
54.4 (2.02) / 57.8 (1.78)
|
26 / 25
|
Korea / prediabetes
|
Parallel
|
1.5 g/d
|
12 weeks
|
Glucose, Insulin and HbA1c
|
Recruited from Hospital and advertisement in local newspapers
|
Decrease:Glucose and HbAIc;No effect: Insulin
|
|
Bays-4.5 g [39]
|
2013
|
49.1 (11.2) / 52.0 (11.3)
|
35 / 33
|
USA / dyslipidemia
|
Parallel
|
4.5 g/d
|
6 weeks
|
Glucose and Insulin
|
Recruited in response to advertisements or from study site databases
|
No effect
|
|
Bays-1.5 g [39]
|
2013
|
50.9 (10.3) / 52.0 (11.3)
|
35 / 32
|
USA / dyslipidemia
|
Parallel
|
1.5 g/d
|
6 week
|
Glucose and Insulin
|
Recruited in response to advertisements or from study site databases
|
No effect
|
|
Hernández-González [32]
|
2010
|
46.1 (6.3) /41.6 (6.3)
|
6月6日
|
Mexico / obese
|
Parallel
|
2.25 g/d
|
13 weeks
|
Glucose
|
Not stated
|
No effect
|
|
Lehtimäki-carrier [29]
|
2005
|
43.5 (8.8) / 43.9 (8.9)
|
29 / 29
|
Finn / hypercholesterolaemic
|
Crossover
|
2.4 g/d
|
13 weeks
|
Glucose
|
Invitation letters
|
No effect
|
|
Lehtimäki-noncarrier [29]
|
2005
|
44.8 (7.7) / 45.0 (7.8)
|
55 / 55
|
Finn/hypercholesterolaemic
|
Crossover
|
2.4 g/d
|
13 weeks
|
Glucose
|
Invitation letters
|
No effect
|
|
Mhurchu [34]
|
2004
|
47 (11.7) / 48 (11.5)
|
116 / 118
|
New Zealand / overweight and obese
|
Parallel
|
3 g/d
|
24 weeks
|
Glucose
|
Recruited using newspaper advertisements
|
Decrease
|
|
Metso [40]
|
2003
|
46 (8)
|
90 / 93
|
Finland / hypercholesterolaemic
|
Crossover
|
1.2 g/d
|
13 weeks
|
Glucose
|
Invitation letters
|
No effect
|
|
Ho [43]
|
2001
|
43.3(7.7) / 42.6(6.7)
|
32/36
|
Singapore/Obesity
|
Parallel
|
0.25 g/d
|
16 weeks
|
Insulin
|
Recruited from the general public by advertisement
|
No effect
|
|
Jeong [37]
|
2019
|
28.6(1.49)/28.6(1.49)
|
19/19
|
Korea/prediabetes
|
Crossover
|
0.25 g/d
|
2 weeks
|
Glucose
|
Recruited from the Clinical Nutrigenetics/Nutrigenomics Laboratory at Yonsei University
|
Decrease
|
